The question of killing the pain was important for people in all the centuries. Nowadays medicine can offer a number of analgesics, which help to deaden the pain. But it's necessary to consult a doctor before taking them as it may lead to negative consequences. Furthermore, you may have contraindications for taking some of the painkillers.

Strong medications, such as narcotic drugs (morphene, tramadol) are important ingredients of analgesics. They affect the nervous system and block some parts of it. And it's only a doctor who can choose a pain killer to the type of pain. Otherwise, side effects or negative consequences are inevitable.

Analgesics include 2 major classes of painkillers: Paracetamol and NSAID. Parecetamol has some insignificant side effects and that's why it's considered to be harmless. There are also COX2 inhibitors which are the derivatives from NSAID. The negative side about them is that they produce more side effects (e.g. blood clotting) than NSAID. People with special medical treatment need special painkilling drugs: carbamazepine, gabapentin, pregabalin, Tricyclic antidepressants. They are used to ease pain mildly with fewer side effects. Sometimes, in order to improve the painkilling effect, analgesics are used in a combination with each other.

Some of the drugs in the combination may cause inconvenience that's why they go together with other drugs, which ease the inconvenience effect and help to kill the pain.